Antagonists who are geniuses, but not much besides their intellect.
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- Madame Gasket
- Maestro Forte
- Major Timothy Cain
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- Mandark
- Marie Barone
- Mason Verger
- Mason Verger (Hannibal TV show)
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- Max (Total Drama)
- Mayor Humdinger
- Mayor Tortoise John
- Megan Parker
- Megavolt
- Michael Langdon
- Mitch Leary
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- Monica (The Casagrandes)
- Montana Max
- Mozenrath
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- Mr. Toggle
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- Muzan Kibutsuji
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- S.U.S.P.E.N.S.E.
- Salem
- Saruman (Middle-earth)
- Sasuke Uchiha
- Satan (The Passion of the Christ)
- Sauron (Middle-earth)
- Scarecrow (DC)
- Scarecrow (Marvel)
- Schneizel el Britannia
- Scorpion (Mortal Kombat: Defenders of the Realm)
- Serges (Megaman X2)
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- Shauna Krawly
- Sir Miles Axlerod
- Snipe Anteator
- Snoke
- Steven Jacobs
- Sugar Man
- Syndrome (LEGO The Incredibles)