Dio Brando known simply as DIO from Part 3-onwards, is the main antagonist of Parts 1 and 3 of JoJo's Bizarre Adventure, though his legacy causes repercussions throughout the rest of the series as well making the main villain of the whole series. He is also the father of Part 5's protagonist Giorno Giovanna. He has an alternative version of him called Diego Brando in Part 7. He also have three other sons in Part 6 under the rule of his friend Enrico Pucci.
In Eyes of Heaven, he has an ultimate form called Heaven Ascension DIO, which serves as the main villain of that game.