Dr. Julius No is the main and eponymous antagonist in the first James Bond film, Dr. No, played by Joseph Wiseman. He works for the evil organization SPECTRE, who profited off of playing the United States and the USSR against each other.
Dr. No was born in China to the daughter of a wealthy Chinese family and a German missionary. Such half-breed status precluded him from many activities, but his skill with numbers gained him the position of accountant for a local Triad, or crime family. He stole a large sum of money from them, which forced Dr. No to leave China. It was about this time that SPECTRE picked him up to work for their espionage department.
After working on various projects for SPECTRE around the world, Dr. No was sent by his superiors to Crab Key, an island they had bought off Jamaica. Here he was to orchestrate a project using radioactive beams to interfere with US space program in Cape Canaveral, funded with Soviet money. He had a local British official murdered when he got too close to the truth. This caused Britain's MI-6 to send James Bond, agent 007, to investigate.
Clash with BondEdit
Upon Bond's arrival in Jamaica, Dr. No made several attempts to assassinate him. When all of these attempts failed, Dr. No left bond come to him. When Bond finally arrived on Crab Key, Dr. No had him captured and brought to him, where he offered him a position in SPECTRE.
When Bond wittily refused, No had him locked up in a cell while he went to work on the project's latest phase, to bring one of NASA's gemini rockets. Bond escaped from his cell and tampered with Dr. No's machinery, which began to self destruct. Bond and No ended up fighting over his boiling reactor coolant as his nuclear reactor overheated. He fell into the coolant and was boiled alive, unable to get a firm grip on anything with his slick, metallic hands.