Dr. Nefarious is the main antagonist of the Ratchet & Clank franchise originally making his debut as the main antagonist of Ratchet & Clank: Up Your Arsenal. He is a robotic mad scientist and the archenemy of Qwark, Ratchet and Clank who wishes to destroy all organic life (which he refers to as squishies) and take over the world. He's the main antagonist of Ratchet & Clank: Up your Arsenal and Ratchet & Clank: A Crack in Time, a cameo character in Ratchet: Dreadlocked, the tretagonist / antihero in Ratchet & Clank: All 4 One and the secondary antagonist turned antihero in Ratchet and Clank: Rift Apart. Dr. Nefarious (movie)